Inhalable chitosan microparticles for simultaneous delivery of isoniazid and rifabutin in lung tuberculosis treatment
نویسندگان
چکیده
منابع مشابه
Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice.
Intracellular concentrations of isoniazid and rifabutin resulting from administration of inhalable microparticles of these drugs to phorbol-differentiated THP-1 cells and the pharmacokinetics and biodistribution of these drugs upon inhalation of microparticles or intravenous administration of free drugs to mice were investigated. In cultured cells, both microparticles and dissolved drugs establ...
متن کاملInhalable microparticles containing isoniazid and rifabutin target macrophages and 'stimulate the phagocyte' to achieve high efficacy.
Macrophage responses to infection with Mycobacterium tuberculosis (MTB) and treatment with soluble isoniazid (INH) plus rifabutin (RFB) versus microparticles containing equivalent amounts of drugs were compared. It was investigated whether macrophages driven to alternative activation upon infection with MTB could be rescued to display the classical activation phenotype. It was established that ...
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SiRNA-based strategies appear to be an exciting new approach for the treatment of respiratory diseases. To extrapolate siRNA-mediated interventions from bench to bedside in this area, several aspects have to be jointly considered, including a safe and efficient gene carrier with pulmonary deposition efficiency, as well as in vivo method for siRNA/nanoparticles delivery. Accordingly, in this wor...
متن کاملInhalable microparticles containing large payload of anti-tuberculosis drugs.
Microparticles containing large payloads of two anti-tuberculosis (TB) drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages. A solution containing one part each of isoniazid and rifabutin, plus two parts poly(lactic acid) (L-PLA) was spray-dried. Drug content and in vitro release were assayed by HPLC, and DSC was used to elucidate release b...
متن کاملIsoniazid loaded chitosan microspheres for pulmonary delivery: Preparation and characterization
The objective of the present study was to entrap isoniazid, an Antitubercular drug, in cross linked chitosan matrix and study in vitro lung deposition of powdered chitosan microspheres using Andersen cascade impactor. Ionic cross linker Tripolyphospate was used to make cross linked chitosan microspheres to achieve sustained drug release. Chitosan microspheres were prepared by spray drying metho...
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ژورنال
عنوان ژورنال: Drug Development and Industrial Pharmacy
سال: 2019
ISSN: 0363-9045,1520-5762
DOI: 10.1080/03639045.2019.1608231